2015-07-01 19:58:04 UTC

July 15, 2015

Here’s how one young investigator is using her grant from the AGA Research Foundation.

AGA would like to highlight Christina A. Twyman-Saint Victor, MD, from the University of Pennsylvania, a proud recipient of the 2015 AGA Research Scholar Award.

Dr. Twyman-Saint Victor’s research focuses on pancreatic cancer, which has a dismal prognosis and is expected to be the second leading cause of cancer-related deaths by 2020. Despite advances in its management, most patients are resistant to treatment and the immunosuppressive tumor microenvironment plays an integral role in this resistance.

Dr. Twyman-Saint Victor and her team are exploring a novel treatment option designed to harness the immune response using immunotherapy and radiotherapy to create an anti-tumor immune response. Despite promising results in their animal models, resistance to treatment still occurs. To better understand mechanisms of resistance to combined radiotherapy and immunotherapy, this project will investigate how mechanistically radiotherapy affects response to immunotherapy. The information gained will be used to devise rationale and novel treatment regimens for pancreatic ductal adenocarcinoma that can be applied to the development of clinical trials.

Dr. Twyman-Saint Victor would like to thank the AGA Research Foundation for supporting her research as she transitions to an independent physician-researcher.

If you’d like to support young researchers such as Dr. Twyman-Saint Victor, make a donation to the AGA Research Foundation.

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